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Vitamin E and cognitive decline in older persons.

Martha Clare Morris1, Denis A Evans, Julia L Bienias

  • 1Department of Preventive medicine, Rush Institute for Healthy Aging, Rush-Presbyterian-St Luke's Medical Center, 1645 W Jackson, Suite 675, Chicago, IL 60612, USA. mmorris@rush.edu

Archives of Neurology
|July 16, 2002
PubMed
Summary

Higher vitamin E intake is linked to slower cognitive decline in older adults. This antioxidant may play a role in preserving brain function with age.

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Area of Science:

  • Gerontology
  • Nutritional Neuroscience
  • Cognitive Aging

Background:

  • Emerging evidence suggests antioxidants may offer protection against neurodegenerative diseases.
  • Investigating the role of specific antioxidant nutrients in cognitive health is crucial.

Purpose of the Study:

  • To determine if antioxidant nutrient intake, specifically vitamin E, vitamin C, and carotene, correlates with reduced age-related cognitive decline.
  • To analyze the association between dietary antioxidant intake and cognitive function over time.

Main Methods:

  • A longitudinal population-based study was conducted with 2889 community residents aged 65-102.
  • Cognitive function was assessed using four standardized tests at baseline and at 3-year follow-up.
  • Dietary intake, including antioxidant nutrients, was evaluated using a food frequency questionnaire.

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Main Results:

  • Higher intake of vitamin E was significantly associated with a reduced rate of cognitive decline (36% reduction in the highest vs. lowest quintile).
  • This association remained significant after adjusting for various lifestyle and demographic factors.
  • No significant association was found between vitamin C or carotene intake and cognitive decline.

Conclusions:

  • Vitamin E intake, whether from food or supplements, is associated with less cognitive decline in aging individuals.
  • These findings highlight the potential neuroprotective benefits of vitamin E in maintaining cognitive function in later life.