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About the use of protein models
1Novartis Pharma AG, WKL-490.4.04, 4002 Basel, Switzerland Swiss Institute of Bioinformatics, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. manuel.peitsch@pharma.novartis.com
Bioinformatics (Oxford, England)
|July 16, 2002
Summary
Protein models aid functional genomics by offering structural insights for protein function. Their accuracy, though not perfect, is well-understood and impacts their utility in various applications.
Area of Science:
- Structural biology
- Functional genomics
- Computational biology
Background:
- Protein models are crucial for understanding protein function through structural insights.
- Comparative modeling is the most reliable method for predicting protein structures.
- The quality and accuracy of protein models are increasingly well-understood.
Purpose of the Study:
- To highlight the importance of protein models in functional genomics.
- To discuss the reliability and understanding of comparative modeling techniques.
- To explain how model correctness and accuracy influence their application.
Main Methods:
- Utilizing comparative modeling for protein structure prediction.
- Classifying protein models based on correctness and accuracy.
- Assessing the impact of model quality on functional genomics applications.
Main Results:
- Protein models provide essential structural information for functional genomics.
- Comparative modeling, while imperfect, is a well-understood and reliable technique.
- The accuracy of protein models directly correlates with their usefulness.
Conclusions:
- Protein models are valuable tools in functional genomics.
- Understanding protein model quality is key to their effective application.
- Accurate protein models enhance the study of protein function.