Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacogenomics.

Olivier Tribut1, Yvon Lessard, Jean-Michael Reymann

  • 1Department of Pharmacology, Medical Faculty, Rennes I University, France.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|July 18, 2002
PubMed
Summary

Pharmacogenomics uses DNA to predict individual drug responses, moving beyond simple responders/non-responders. This advances personalized medicine by guiding drug choice, dosage, and regimen for better outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Therapeutic drug monitoring of olanzapine].

Therapie·2016
Same author

[Therapeutic drug monitoring of clozapine].

Therapie·2016
Same author

[Not Available].

Therapie·2016
Same author

[Not Available].

Therapie·2016
Same author

[Not Available].

Therapie·2016
Same author

Suivi thérapeutique pharmacologique du zonisamide.

Therapie·2016

Area of Science:

  • Pharmacology
  • Genetics
  • Biotechnology

Background:

  • Pharmacogenomics is revolutionizing medicine with molecular biotechnologies like DNA chips.
  • It shifts focus from responders/non-responders to individualized patient responses.
  • This enables a move towards predictive and personalized medicine.

Purpose of the Study:

  • To review pharmacogenomic applications in various medical fields.
  • To highlight the role of genetic polymorphisms in drug metabolism and response.
  • To discuss the impact of pharmacogenomics on drug development.

Main Methods:

  • Review of scientific literature on pharmacogenomics.
  • Analysis of genetic polymorphisms in drug-metabolizing enzymes (e.g., cytochrome P450).

Related Experiment Videos

  • Examination of genotype-phenotype correlations for drug targets (receptors, transporters).

    • Main Results:

    • Genetic variations, particularly in cytochrome P450 enzymes, explain many drug response differences.
    • Polymorphisms in dopaminergic receptors (neuropsychopharmacology) and beta2-adrenergic receptors (asthma) affect drug efficacy and adverse reactions.
    • Pharmacogenomics is crucial in cardiovascular diseases (ion channels), cancer predisposition, and addiction research.

    Conclusions:

    • Pharmacogenomics enables personalized medicine by predicting individual drug benefits and risks.
    • Advances in phenotyping and genotyping will improve diagnosis and treatment strategies.
    • This field significantly impacts preclinical and clinical drug development methodologies.