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Direct conversion of macrocyclic furans into macrocyclic isothiazoles
Jérôme Guillard1, Otto Meth-Cohn, Charles W Rees
1Chemistry Department, University of Sunderland, Sunderland, UK SR1 3SD.
Chemical Communications (Cambridge, England)
|July 18, 2002
Abstract:
The first calixhetarenes with more than one heteroatom in the constituent rings are prepared in one step by treatment of calix[4]furan 1a and calix[6]furan 1b with ethyl carbamate, thionyl chloride and pyridine to give 2, 3, 4 and 5, 6, 7 respectively; these products have been characterised by X-ray crystallography which reveals that in 2 all eight heteroatoms lie on one face of the macrocyle.