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Oligodeoxynucleotides containing amide-linked LNA-type dinucleotides: synthesis and high-affinity nucleic acid
Anne Lauritsen1, Jesper Wengel
1Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark.
Chemical Communications (Cambridge, England)
|July 18, 2002
Abstract:
Synthesis of three different amide-linked LNA-type dinucleotides and their incorporation into 9-mer and 17-mer oligodeoxynucleotides is described; compared to the reference DNA-RNA duplex, incorporation of one of the three dimers (5'-DNA*LNA dimer) induced significantly increased duplex thermostabilities.