Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell fusion: an EFFicient sculptor.

Eric Witze1, Joel H Rothman

  • 1Department of MCD Biology, University of California, Santa Barbara 93106, USA.

Current Biology : CB
|July 18, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence that local viscosity and NOX-dependent ROS increases render the tardigrade H. exemplaris resilient to extreme physical force.

bioRxiv : the preprint server for biology·2026
Same author

Multimodal sensory inputs and mechanosensory components mediate <i>C. elegans</i> negative gravitaxis.

iScience·2025
Same author

Single-Animal, Single-Tube RNA Extraction for Comparison of Relative Transcript Levels via qRT-PCR in the Tardigrade Hypsibius exemplaris.

Journal of visualized experiments : JoVE·2025
Same author

Single-animal, single-tube RNA extraction for comparison of relative transcript levels via qRT-PCR in the tardigrade <i>Hypsibius exemplaris.</i>

bioRxiv : the preprint server for biology·2024
Same author

Regulation of defective mitochondrial DNA accumulation and transmission in <i>C. elegans</i> by the programmed cell death and aging pathways.

eLife·2023
Same author

Expression of the <i>odd-2</i> Gene in <i>C. elegans</i>.

microPublication biology·2023
Same journal

A global response contributes to tissue size robustness upon local induction of apoptosis.

Current biology : CB·2026
Same journal

Prebilaterian origin of monoaminergic signaling.

Current biology : CB·2026
Same journal

CLASP-dependent microtubule stabilization generates microtubule-based protrusive forces during Drosophila epithelial morphogenesis.

Current biology : CB·2026
Same journal

Pigeons make slow, divergent eye movements during flight and large, convergent eye movements when landing.

Current biology : CB·2026
Same journal

Temperature signals drive grass secondary cell wall thickening.

Current biology : CB·2026
Same journal

Neuronal RNAi and oxygen-sensing circuit shape germline resilience to heat stress.

Current biology : CB·2026
See all related articles

Mutations in the eff-1 gene of Caenorhabditis elegans block all epidermal cell fusions, revealing critical roles for this process in development. The EFF-1 protein

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Cell-cell fusion is essential for development in multicellular organisms.
  • The eff-1 gene in Caenorhabditis elegans is known to be involved in epidermal cell fusions.

Purpose of the Study:

  • To investigate the developmental roles of cell-cell fusion mediated by the eff-1 gene.
  • To explore the mechanism by which EFF-1 facilitates cell fusion.

Main Methods:

  • Utilizing genetic mutations in the eff-1 gene in Caenorhabditis elegans.
  • Analyzing the effects of these mutations on epidermal development.
  • Investigating the protein structure of EFF-1, focusing on its extracellular domain.

Main Results:

Related Experiment Videos

  • Mutations in eff-1 completely abolish cell-cell fusion in the nematode epidermis.
  • This disruption highlights significant developmental functions of cell fusion.
  • The EFF-1 protein possesses an extracellular fusogen-like domain.

Conclusions:

  • Cell-cell fusion is a crucial developmental process in nematode epidermis.
  • The EFF-1 protein, with its fusogen-like domain, likely directs the fusion of lipid bilayers during development.