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The versatile conversion of acyclic amides to alpha-alkylated amines
Young-Ger Suh1, Dong-Yun Shin, Jae-Kyung Jung
1College of Pharmacy, Seoul National University, San 56-1, Shinlim-dong, Kwanak-Gu, Seoul, Korea. ygsuh@snu.ac.kr
Abstract:
A general and efficient method for the versatile functionalization of acyclic amide via N,O-acetal TMS ether, an excellent precursor for the N-acyliminium ion, has been developed.