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Updated: Aug 27, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Scoring of chronic hepatitis
Peter J Scheuer1, Richard A Standish, Amar P Dhillon
1Department of Histopathology, Royal Free Hospital, Pond Street, London NW3 2QG, UK. scheuer@scheupj.demon.co.uk
Abstract:
Grading of the severity of chronic hepatitis and staging of its structural consequences are widely used in clinical trials of therapy and in research. Simple and complex methods are available. Intra- and interobserver variation can be reduced but not eliminated, because grading and staging are essentially subjective. The data are categorical rather than numerical and must be treated accordingly. Morphometry of fibrous tissue offers a different approach to biopsy assessment.
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