Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Criteria for evaluating deviations from good laboratory practice].

Alberto Mantovani1

  • 1Laboratorio di Tossicologia Comparata ed Ecotossicologia, Istituto Superiore di Sanità, V.le Regina Elena 299, 00161 Roma. alberto@iss.it

Annali Dell'Istituto Superiore Di Sanita
|July 19, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Why research on Endocrine Disrupting Chemicals is still worthwhile. Editorial.

Annali dell'Istituto superiore di sanita·2017
Same author

Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects.

eLife·2017
Same author

Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice.

Intensive care medicine experimental·2017
Same author

Driver mutations (JAK2V617F, MPLW515L/K or CALR), pentraxin-3 and C-reactive protein in essential thrombocythemia and polycythemia vera.

Journal of hematology & oncology·2017
Same author

Analysis of Food Safety and Security Challenges in Emerging African Food Producing Areas through a One Health Lens: The Dairy Chains in Mali.

Journal of food protection·2017
Same author

The Hotspot for (Global) One Health in Primary Food Production: Aflatoxin M1 in Dairy Products.

Frontiers in public health·2017
Same journal

External quality assessment programs in cytogenomics in the Lombardy Region, Italy (2018-2024): performance and trends.

Annali dell'Istituto superiore di sanita·2026
Same journal

Spontaneous orienting of untrained companion dogs naïve to human epilepsy toward odor samples from an unfamiliar human in a controlled non-social paradigm: a proof-of-concept.

Annali dell'Istituto superiore di sanita·2026
Same journal

Addressing food and nutrition insecurity in European countries: a scoping review of strategies and policies.

Annali dell'Istituto superiore di sanita·2026
Same journal

Women's experiences of membrane sweeping for labour induction: a phenomenological qualitative study.

Annali dell'Istituto superiore di sanita·2026
Same journal

Evaluating the usefulness of the Mediterranean Diet Quality Index (KIDMED) in assessing eating habits and nutritional status among preschool children.

Annali dell'Istituto superiore di sanita·2026
Same journal

Optimizing sample preparation for homogeneous mycotoxin distribution in official control analyses.

Annali dell'Istituto superiore di sanita·2026
See all related articles

Ensuring compliance with Good Laboratory Practice (GLP) involves assessing test facilities for deviations that impact data quality. Key areas include personnel training, basic procedures, and specific study types, especially for new guidelines like endocrine testing.

Area of Science:

  • Laboratory Science
  • Regulatory Compliance
  • Toxicology

Context:

  • Assessing compliance with Good Laboratory Practice (GLP) is crucial for scientific data integrity.
  • Inspections require integrating diverse observations into a comprehensive facility assessment.
  • Deviations from GLP can jeopardize the scientific quality and reliability of study data.

Purpose:

  • To detail major types of deviations from Good Laboratory Practice (GLP) principles.
  • To highlight how these deviations can compromise the scientific quality of data.
  • To examine the impact of evolving guidelines, such as those for endocrine disruptor testing, on facility requirements.

Summary:

  • Identifies three major categories of GLP deviations: misunderstanding principles (e.g., training), inadequate application to procedures (e.g., lab hygiene), and issues with specific study types.

Related Experiment Videos

  • Emphasizes that even minor deviations can indicate a lack of understanding of GLP.
  • Discusses how new guidelines, like those for endocrine effects, necessitate updated quality requirements, structures, and personnel expertise (e.g., hormonal assays).

    • Impact:

    • Provides a framework for identifying and rectifying GLP non-compliance issues in testing facilities.
    • Ensures the scientific validity and regulatory acceptance of research data.
    • Guides facilities in adapting to new regulatory demands and technological advancements, particularly in specialized testing areas like endocrinology.