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The in situ oxidation-Wittig reaction of alpha-hydroxyketones
Karen A Runcie1, Richard J K Taylor
1Department of Chemistry, University of York, Heslington, York, UK YO10 5DD.
Chemical Communications (Cambridge, England)
|July 19, 2002
Abstract:
In situ oxidation-Wittig methodology has been applied to alpha-hydroxyketones avoiding the problems normally associated with alpha-ketoaldehydes; the procedure is practically simple, and in many cases gives high yields of the product gamma-ketocrotonates; the procedure has also been successfully utilised with ethyl glycolate and glycolaldehyde dimer.