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Efficient enantioselective additions of terminal alkynes and aldehydes under operationally convenient conditions
Dean Boyall1, Doug E Frantz, Erick M Carreira
1Laboratorium für Organische Chemie, ETH-Hönggerberg HCI H335, CH-8093 Zürich, Switzerland.
Organic Letters
|July 19, 2002
Abstract:
[reaction: see text] The enantioselective addition reaction of terminal acetylenes and aldehydes mediated by Zn(OTf)2 and N-methyl ephedrine can be conducted with reagent grade solvent containing 84-1000 ppm H2O. The products can be isolated in high yield and useful enantioselectivities (up to 99% ee).