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Related Experiment Videos

Myc-Is this the oncogene from Hell?

Laura Soucek1, Gerard Evan

  • 1Cancer Research Institute, University of California, San Francisco, Cancer Center, 2340 Sutter Street, 94143, USA.

Cancer Cell
|July 19, 2002
PubMed
Summary
This summary is machine-generated.

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The Myc oncoprotein can directly cause DNA damage and genome instability in cells. Further research is needed to determine if Myc causes similar genetic instability in living organisms.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The Myc oncoprotein is frequently implicated in cancer development.
  • Previous studies suggest Myc can induce DNA damage and genomic instability in cell cultures.

Purpose of the Study:

  • To investigate the role of the Myc oncoprotein in inducing DNA damage and genome instability.
  • To determine if Myc-induced genetic alterations observed in vitro are recapitulated in vivo.

Main Methods:

  • Utilizing cell culture models to assess DNA damage markers.
  • Employing in vivo models to evaluate genome-wide genetic instability.

Main Results:

  • The Myc oncoprotein was found to directly induce DNA damage in cultured cells.

Related Experiment Videos

  • Evidence suggests Myc contributes to genome instability in cellular models.

    • Conclusions:

    • Myc's role in directly inducing DNA damage and genome instability is supported by in vitro data.
    • Further investigation is required to confirm Myc's role in in vivo genome instability.