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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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A simple sensitive program for detecting internal repeats in sets of multiply aligned homologous proteins

Yufeng Zhai1, Milton H Saier

  • 1Division of Biology, University of California at San Diego, La Jolla 92093-0116, USA.

Journal of Molecular Microbiology and Biotechnology
|July 20, 2002
PubMed

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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...