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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
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Published on: April 2, 2012

Pathophysiology of facial nerve paralysis induced by herpes simplex virus type 1 infection

Nobumitu Honda1, Naohito Hato, Hirotaka Takahashi

  • 1Department of Otolaryngology, Ehime University School of Medicine, Japan.

The Annals of Otology, Rhinology, and Laryngology
|July 20, 2002
PubMed

Herpes simplex virus type 1 (HSV-1) has been proven to be a cause of Bell's palsy; however, the underlying pathophysiology of the facial nerve paralysis is not fully understood. We established a mouse model with facial nerve paralysis induced by HSV-1 infection simulating Bell's palsy and investigated the pathophysiology of the facial nerve paralysis. The time course of the R1 latency in the blink reflex tests paralleled the recovery of the facial nerve paralysis well, whereas electroneurographic recovery tended to be delayed, compared to that of the paralysis; these responses are usually seen in Bell's palsy. On histopathologic analysis, intact, demyelinated, and degenerated nerves were intermingled in the facial nerve in the model. The similarity of the time course of facial nerve paralysis and the electrophysiological results in Bell's palsy and the model strongly suggest that the pathophysiological basis of Bell's palsy is a mixed lesion of various nerve injuries.

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