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Preparation of 7-alkylamino-2-methylquinoline-5,8-diones
Han Young Choi1, Dong Wook Kim, Dae Yoon Chi
1Division of Applied Sciences, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 136-791, Korea.
The Journal of Organic Chemistry
|July 20, 2002
Abstract:
Several novel 7-alkylamino-2-methylquinoline-5,8-diones (2) were synthesized from 2,5-dimethoxyaniline in five steps via the Skraup reaction followed by demethylations, oxidative bromination, amination, and debromination. We have achieved an unusual hydrobromic acid catalyzed debromination reactions of several 6-bromo-7-alkylamino-2-methylquinoline-5,8-diones, giving 7-alkylamino-2-methylquinoline-5,8-diones in good yields.