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An improved protocol for the preparation of 3-pyridyl- and some arylboronic acids
Wenjie Li1, Dorian P Nelson, Mark S Jensen
1Process Research Department, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. wenjie_li@merck.com
The Journal of Organic Chemistry
|July 20, 2002
Abstract:
3-Pyridylboronic acid was prepared in high yield and bulk quantity from 3-bromopyridine via a protocol of lithium-halogen exchange and "in situ quench". This technique was further studied and evaluated on other aryl halides in the preparation of arylboronic acids.