Nonvalvular Intravascular Device-related Infections

Nonvalvular intravascular devices are in widespread use in developed countries and are now more commonly employed than are prosthetic cardiac valves. Although the variety of devices that are included in the category of "nonvalvular" represent a heterogenous collection, there is commonality among several of the devices. This includes their requirement to sustain life and the need for removal for cure if they become infected, which is often due to multidrug-resistant microorganisms. Thus, infection of these devices often presents difficult treatment scenarios. This update will address the pathogenesis and immunobiology of nonvalvular intravascular device-related infections and the epidemiology and treatment of infections of several of these devices that include pacemakers, implantable cardioverter defibrillators, intravascular catheters, vascular grafts and stents, and left ventricular assist devices.