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C/T polymorphism of the intercellular adhesion molecule-1 gene (exon 6, codon 469). A risk factor for coronary heart

Hong Jiang1, Rolf Michael Klein, Dieter Niederacher

  • 1Heart Center Wuppertal, University of Witten-Herdecke, Arrenbergerstr. 20, 42117 Wuppertal, Germany. hong.jiang@uni-duesseldorf.de

International Journal of Cardiology
|July 20, 2002
PubMed

Insights

The intercellular adhesion molecule-1 (ICAM-1) C/T gene polymorphism is linked to increased risk of coronary heart disease (CHD) and myocardial infarction (MI). Individuals with TT or TC genotypes show higher susceptibility to these cardiovascular conditions.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Molecular Biology

Background:

  • Intercellular adhesion molecule-1 (ICAM-1) is crucial in endothelial cell-leukocyte interactions and coronary atherosclerosis pathogenesis.
  • A known C/T polymorphism in ICAM-1 exon 6 codon 469 results in an amino acid substitution.
  • Understanding genetic predispositions for cardiovascular disease is vital.

Purpose of the Study:

  • To investigate if the ICAM-1 C/T polymorphism influences the risk of coronary heart disease (CHD).
  • To determine the association between the ICAM-1 C/T polymorphism and myocardial infarction (MI) risk.

Main Methods:

  • Genotyping of ICAM-1 polymorphism using polymerase chain reaction and allele-specific oligonucleotide techniques.
  • Case-control study design involving 349 CHD patients (179 with MI) and 213 controls.
  • Statistical analysis including multivariable logistic regression.

Main Results:

  • Frequencies of the T genotype (TT+TC) were significantly higher in CHD and MI patients compared to controls (P<0.001).
  • Multivariable logistic regression confirmed a significant association between CHD/MI and TT/TC genotypes (P=0.011, OR 2.21).

Conclusions:

  • The TT and TC genotypes of the ICAM-1 gene polymorphism at codon 469 are associated with increased susceptibility to CHD.
  • This ICAM-1 polymorphism may serve as a genetic marker for predicting individual risk of coronary heart disease and myocardial infarction.
Abstract

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