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N-thiolated beta-lactams: novel antibacterial agents for methicillin-resistant Staphylococcus aureus
Edward Turos1, Timothy E Long, Monika I Konaklieva
1Department of Chemistry, 4202 E. Fowler Avenue, University of South Florida, Tampa, FL 33620, USA. eturos@chuma.cas.usf.edu
Bioorganic & Medicinal Chemistry Letters
|July 20, 2002
Abstract:
In this report we describe a new family of N-thiolated beta-lactams that have antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). The compounds show unprecedented structure-activity features and an unusual mode of action for a beta-lactam antibiotic.