Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An 'oligarchy' rules neural development.

David H Rowitch1, Q Richard Lu, Nicoletta Kessaris

  • 1Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. david_rowitch@dfci.harvard.edu

Trends in Neurosciences
|July 20, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myelin basic protein is an RNA chaperone in microglial nuclear retro-transport.

bioRxiv : the preprint server for biology·2026
Same author

Consensus statement on microglial and macrophage functions in gliomas.

Acta neuropathologica·2026
Same author

DNA damage burden causes selective CUX2 neuron loss in neuroinflammation.

Nature·2026
Same author

Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair.

Nature·2026
Same author

Tunable hydrogel-based micropillar arrays for myelination studies.

Nature methods·2026
Same author

Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma.

Nature·2026
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
Same journal

The neural basis of laughter.

Trends in neurosciences·2026
See all related articles

Olig genes are crucial for oligodendrocyte development and surprisingly also for motor neuron formation. This discovery reshapes understanding of neuron-glia developmental links.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Olig genes encode transcription factors vital for oligodendrocyte development.
  • Previous research established Olig's role in glial cell formation.

Purpose of the Study:

  • To investigate the full functional spectrum of Olig transcription factors.
  • To explore the role of Olig genes beyond oligodendrocyte development.

Main Methods:

  • Analysis of Olig gene expression patterns.
  • Genetic manipulation studies in developmental models.

Main Results:

  • Olig genes are confirmed essential for oligodendrocyte lineage development.
  • Unexpectedly, Olig gene function was found to be critical for somatic motor neuron formation.

Related Experiment Videos

  • Demonstrated a previously unrecognized requirement for Olig in motor neuron differentiation.

    • Conclusions:

    • Olig transcription factors play a dual role in central nervous system development.
    • Findings challenge existing models of neurogenesis and gliogenesis.
    • Suggests intricate developmental crosstalk between neuronal and glial precursor cells.