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Using genetic variation to study immunomodulation.

Stephen Chanock¹, James G Taylor

¹Section on Genomic Variation, Pediatric Oncology Branch, National Cancer Institute, Advanced Technology Center, 8717 Grovemont Circle, Gaithersburg, MD 20877, USA. sc83a@nih.gov

Current Opinion in Pharmacology

|July 20, 2002

Summary

This summary is machine-generated.

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See all related articles

The human genome

Area of Science:

Genomics
Immunology
Complex Diseases

Background:

The human genome draft sequence revealed millions of common variants.
Single nucleotide polymorphisms (SNPs) are key genetic variations.
SNPs offer a resource for studying complex diseases.

Purpose of the Study:

To investigate the determinants of human immune response.
To utilize high-density variant maps for quantitative analysis.
To identify novel therapeutic targets for immune-related conditions.

Main Methods:

Genome-wide variant mapping.
Quantitative analysis of genetic determinants.
Focus on candidate genes and chromosomal regions.

Related Experiment Videos

Main Results:

Identification of millions of common single nucleotide polymorphisms (SNPs).
Establishment of a resource for complex disease research.
Foundation for investigating immune response determinants.

Conclusions:

High-density variant maps facilitate immune response research.
Quantitative analysis of SNPs can uncover disease mechanisms.
This approach holds potential for identifying new therapeutic targets.