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First synthesis of (+)-alpha- and (+)-gamma-polypodatetraenes
Masako Kinoshita1, Mahisa Ohtsuka, Daisuke Nakamura
1School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan.
Chemical & Pharmaceutical Bulletin
|July 20, 2002
Abstract:
First synthesis of (+)-alpha-polypodatetraene (1) and (+)-gamma-polypodatetraene (2) was achieved from (+)-albicanol (6) and (-)-drimenol (8), respectively. The absolute structure of natural (+)-2 was established to be (5S,9S,10S)-polypoda-7,13(E),17(E),21-tetraene.