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Improved preparation of an amino acid type poly(ethylene glycol) derivative
Keiko Hojo1, Yuichi Susuki, Masahiko Sasaki
1Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University, Japan.
Chemical & Pharmaceutical Bulletin
|July 20, 2002
Abstract:
An amino acid type poly(ethylene glycol) is a useful tool for preparation of a bi- or multivalent poly(ethylene glycol) hybrid of bioactive peptides, but synthesis is problematic. The amino acid type poly(ethylene glycol) was prepared from poly(oxyethylene)diglycolic acid followed by introduction of a fluorenylmethyloxycarbonyl group. The resulting product could be purified easily by LH-20 column chromatography and HPLC.