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Related Experiment Videos

Cardiovascular depression resulting from atenolol intoxication.

J N Love1, J Elshami

  • 1Department of Emergency Medicine, Georgetown University Hospital, 3800 Reservoir Rd, NW, Washington, DC 20007, USA.

European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
|July 20, 2002
PubMed
Summary

Massive atenolol ingestion caused hypotension and ECG changes, mimicking lipophilic beta-blockers. Even hydrophilic atenolol may possess membrane-stabilizing activity at higher doses, explaining haemodynamic depression.

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Area of Science:

  • Cardiology
  • Clinical Pharmacology

Background:

  • Beta-blockers are widely used for cardiovascular conditions.
  • Lipophilic beta-blockers like propranolol are known for membrane-stabilizing activity.
  • Hydrophilic beta-blockers, such as atenolol, are generally believed to lack this activity.

Observation:

  • A case of massive atenolol ingestion presented with hypotension.
  • Electrocardiogram (ECG) showed PR and QRS interval prolongation.
  • These findings mimicked the effects of lipophilic beta-blockers.

Findings:

  • The case suggests hydrophilic beta-blockers may possess membrane-stabilizing activity.
  • Literature review indicates higher concentrations of hydrophilic agents are needed for this effect.
  • A potential pathophysiological basis for atenolol-induced haemodynamic depression is proposed.

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Implications:

  • This challenges the traditional view of hydrophilic beta-blockers.
  • Understanding the dose-dependent membrane-stabilizing effects is crucial for managing overdose.
  • Further research into the electrophysiological properties of beta-blockers is warranted.