Predictors of carpal tunnel syndrome: an 11-year study of industrial workers

In 1984 we initiated a study of factors associated with carpal tunnel syndrome (CTS) in industrial workers by using a case definition based on both symptoms and electrophysiologic findings. Medical history, lifestyle factors, and symptoms were assessed by interview, and electrodiagnostic studies were used to measure median nerve function. Job tasks were classified by both interview and direct observation of work activities. Follow-up evaluations were conducted in 1989 and 1994-1995. The analytic sample consisted of 111 women and 145 men free of CTS in 1984 who were examined at both subsequent contact points. In logistic regression analyses, greater age, female gender, relative overweight, cigarette smoking, and vibrations associated with job tasks were found to significantly increase risk for dominant-hand CTS, whereas presence of an endocrine disorder was marginally related to reduced risk for CTS. These findings were generally similar when analyzed separately for men and women. Similar to other chronic noninfectious diseases, personal factors may play an important role in determining risk for CTS.