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Lethality of yeasts with low pathogenicity in mice immunocompromised by cyclophosphamide treatment
1Second Department of Hygienic Chemistry, Tohoku Pharmaceutical University, Sendai, Miyagi, Japan. okawa@tohoku-pharm.ac.jp
Biological & Pharmaceutical Bulletin
|July 23, 2002
Abstract:
One strain each of Arxiozyma telluris, Saccharomyces cerevisiae, and S. kluyveri showed lethal activity in cyclophosphamide (CY)-treated mice. Accumulation of these yeast cells in the kidneys and elevation of the levels of cytokines, tumor necrosis factor-alpha, and interleukin-1alpha in the sera were recognized in the CY-treated infected-debilitated mice.