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[Association between early-onset coronary heart disease and angiotensin II type 1 receptor gene polymorphism]
Jian Peng1, Shu Peng, Wuxing Gong
1Department of Cardiology, Third Affiliated Hospital of Jinan University Medical College, Zhuhai Municipal People's Hospital, Zhuhai 519000, China.
Insights
This study found no link between the angiotensin II type 1 receptor (ATIR) gene A1166/C polymorphism and early-onset coronary heart disease (CHD). The ATIR gene polymorphism also did not affect plasma lipid levels in patients.
Area of Science:
- Genetics and Cardiovascular Disease
- Molecular Biology
- Biochemistry
Context:
- Early-onset coronary heart disease (CHD) poses a significant health burden.
- The angiotensin II type 1 receptor (ATIR) gene is implicated in cardiovascular regulation.
- Genetic variations, such as polymorphisms, may influence disease susceptibility and progression.
Purpose:
- To investigate the association between the ATIR gene A1166/C polymorphism and the occurrence of early-onset CHD.
- To determine the impact of the ATIR gene A1166/C polymorphism on plasma lipid levels in patients with CHD.
Summary:
- The study analyzed ATIR A1166/C genotypes in 71 early-onset CHD patients, 76 late-onset CHD patients, and 119 controls using PCR-RFLP.
- Genotype and allele frequencies of ATIR A1166/C were similar across all groups.
- No significant differences in plasma lipid levels were observed based on ATIR genotypes in early-onset CHD patients.
Impact:
- The findings suggest that the ATIR gene A1166/C polymorphism is not associated with the development of early-onset CHD.
- This specific ATIR gene polymorphism does not appear to influence plasma lipid profiles in the context of coronary heart disease.
Objective:
To study the association between early-onset coronary heart disease (CHD) and angiotensin II type 1 receptor (ATIR) gene A1166/C polymorphism and the effect of ATIR gene A1166/C on the plasma lipid level.
Methods:
The ATIR A1166/C genotype of 71 early-onset CHD patients, 76 late-onset CHD patients, and 119 controls was examined by PCR-RFLP. Their plasma lipid levels were detected.
Results:
Two ATIR genotypes, AC and AA, were detected. The frequencies (97.2% vs 92.1% vs 94.1%) of genotypes AA and AC and the frequencies of allele A and allele C in the three groups were similar. No difference were found among the levels of plasma lipids in the group of early-onset CHD patients with AA (94.1% vs 5.9%) or AC genotypes (2.8% vs 7.9%).
Conclusion:
There is no association between between ATIR gene A1166/C polymorphism and occurrence of early-onset CHD. ATIR geng A1166/C polymorphism has no effect on plasma lipid levels.