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Published on: March 27, 2018
[Expression and localization of Nogo-A mRNA in rat nerve tissue]
Jian Ye1, Zhengguo Wang, Peifang Zhu
1Research Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Objective:
To investigate the expression and localization of Nogo-A mRNA in brain, spinal cord, optic nerve, and sciatic nerve.
Methods:
Frozen sections of brain, spinal cord, optic nerve, and sciatic nerve of 8 rats were made. In situ hybridization was conducted and the sections were observed by light microscopy.
Results:
The expression of Nogo-A mRNA was positive in brain, spinal cord, and optic nerve, and negative in sciatic nerve.
Conclusion:
The expression of Nogo-A mRNA is negative in brain, spinal cord, and optic nerve, which may be related to the poor axon regeneration in central nervous system.
