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Six new HLA class I alleles detected by PCR-SSO genotyping

C T Kennedy1, W D Greville, R Dodd

  • 1Molecular Genetics, Tissue Typing, Australian Red Cross Blood Service, 153 Clarence Street, Sydney, NSW 2000, Australia.

Tissue Antigens
|July 24, 2002
PubMed

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Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...