Related Experiment Videos
Novel HLA-DRB1 alleles revealed by sequencing based typing, DRB1*04053 and DRB1*1143
W D Greville1, G Chapman, J-P Hogbin
1Molecular Genetics Laboratory, Tissue Typing Services, Australian Red Cross Blood Service, Sydney, Australia. wgreville@arcbs.redcross.org.au
Tissue Antigens
|July 24, 2002
Abstract:
We report the discovery of two HLA-DRB1 alleles by sequencing based typing (SBT). DRB1*04053 differs from previously reported DRB1 alleles by a single synonymous nucleotide substitution, resulting in a unique polymorphism at codon 93. DRB1*1143 differs from previously identified DRB1 alleles by a single non-synonymous nucleotide substitution, resulting in a polymorphism observed in other DRB1 and DRB3 alleles1.