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Related Experiment Videos

Clear cell atypical fibroxanthoma:a clinicopathologic study.

A Neil Crowson1, Kim Carlson-Sweet, Colleen Macinnis

  • 1Department of Dermatology, University of Oklahoma, USA Regional Medical Laboratory, St John Medical Center, 1923 S. Utica Street, Tulsa, OK 74114-4109, USA. ncrowson@sjmc.org

Journal of Cutaneous Pathology
|July 24, 2002
PubMed
Summary

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Clear cell atypical fibroxanthoma (AFX) is a rare skin neoplasm in the elderly. Accurate diagnosis requires immunohistochemistry to differentiate it from other clear cell lesions.

Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Atypical fibroxanthoma (AFX) is typically a superficial variant of malignant fibrous histiocytoma on sun-exposed skin of the elderly.
  • Clear cell AFX is a rare variant that mimics other neoplastic and non-neoplastic clear cell proliferations.

Purpose of the Study:

  • To describe three cases of clear cell AFX.
  • To highlight the diagnostic challenges and differential considerations for this rare entity.

Main Methods:

  • Histopathological analysis of formalin-fixed, paraffin-embedded tissue.
  • Immunohistochemical profiling of tumor cells.

Main Results:

  • Tumors consisted of large cells with foamy cytoplasm and atypical nuclei with frequent mitoses.

Related Experiment Videos

  • Tumor cells expressed CD68 but were negative for CD3, CD20, CD34, S-100, and other markers.

    • Conclusions:

    • Clear cell AFX presents a distinct differential diagnosis from typical AFX, including balloon cell melanoma and sebaceous carcinoma.
    • Immunohistochemistry is crucial for accurate diagnosis and to avoid misclassification and inappropriate treatment.
    • Reporting these cases aims to increase awareness among dermatopathologists for correct diagnosis and management.