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Developmental language disorder associated with polymicrogyria.

M M Guerreiro1, S R V Hage, C A Guimarães

  • 1Department of Neurology, University of Campinas (UNICAMP), SP, Brazil. mmg@fcm.unicamp.br

Neurology
|July 24, 2002
PubMed
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Developmental language disorder (DLD) in children can be linked to polymicrogyria, a brain malformation. The severity of DLD symptoms correlates with the extent of polymicrogyria found via neuroimaging.

Area of Science:

  • Neuroscience
  • Developmental Pediatrics
  • Neuroradiology

Background:

  • Subtle neuronal migration disorders are observed in some dyslexic patients with early childhood developmental language disorder (DLD).
  • Investigating the neuroanatomical basis of DLD is crucial for understanding its underlying mechanisms.

Purpose of the Study:

  • To explore the neuroanatomical substrate of DLD in children using neuroimaging.
  • To correlate imaging findings with clinical DLD manifestations.

Main Methods:

  • Psychological assessment, language evaluation, neurological examination, and magnetic resonance imaging (MRI) were performed.
  • Inclusion criteria included age (≥4 years), primary language delay, normal hearing, IQ >70, and parental consent.
  • Exclusion criteria were severe motor and cognitive handicaps.

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Main Results:

  • Fifteen children (ages 4-14, 11 boys) were included.
  • Six children with diffuse polymicrogyria (PMG) around the sylvian fissure showed severe DLD (e.g., no speech, phonologic-syntactic deficits).
  • Six children with PMG restricted to the posterior parietal regions exhibited milder DLD (phonologic programming deficits). Three had other findings.

Conclusions:

  • Developmental language disorder is associated with polymicrogyria.
  • The clinical presentation of DLD varies based on the extent of polymicrogyria.
  • Posterior parietal PMG represents a mild form of perisylvian syndrome in DLD.