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Lead exposure enhances virus multiplication and pathogenesis in mice
Pratibha Gupta1, M M Husain, Ravi Shankar
1Virology Laboratory, Industrial Toxicology Research Centre, MG Marg, Lucknow, India.
Veterinary and Human Toxicology
|July 26, 2002
Summary
Environmental lead exposure increases susceptibility to viral infections. Studies show lead-exposed mice had higher mortality and faster disease progression when infected with Semliki Forest Virus (SFV).
Area of Science:
- Environmental toxicology
- Immunology
- Virology
Background:
- Environmental xenobiotics can suppress the immune system, increasing host susceptibility to pathogens.
- Lead is a common environmental contaminant with potential immunotoxic effects.
Purpose of the Study:
- To investigate the impact of lead exposure on susceptibility to Semliki Forest Virus (SFV) infection.
Main Methods:
- Mice were orally exposed to varying doses of lead acetate.
- Mice were subsequently challenged with SFV.
- Mortality, survival time, viral titers, and histopathology were assessed.
Main Results:
- Lead-exposed mice showed increased mortality and reduced mean survival time compared to controls.
- Higher viral titers and earlier virus appearance were observed in lead-exposed mice.
- Histopathology revealed dose-dependent enhancement of viral pathogenesis.
Conclusions:
- Lead exposure enhances susceptibility to viral infections, specifically SFV.
- Environmental metal contamination may compromise immune defenses, necessitating further research into pollutant-immune system interactions.