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Massive gabapentin and presumptive quetiapine overdose
Henry A Spiller1, Michael D Dunaway, Letizia Cutino
1Kentucky Regional Poison Center, Louisville, USA.
Veterinary and Human Toxicology
|July 26, 2002
Abstract:
Previous reports of gabapentin overdose have described mild symptoms of somnolence, ataxia and slurred speech. Quetiapine has produced a false positive for cyclic antidepressants on immunoassay drugscreens. Quetiapine overdose is associated with coma, QTc prolongation and hypotension. We report a case of massive gabapentin and presumptive quetiapine overdose with the highest recorded serum gabapentin concentration (104.5 u/ml) associated with coma, respiratory depression requiring mechanical ventilation, and hypotension.