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Alterations in platelet function during the ovarian cycle.

M Feuring1, M Christ, A Roell

  • 1Institute of Clinical Pharmacology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|July 26, 2002
PubMed
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The ovarian cycle alters platelet function, with changes in closure time and increased fibrinogen during the luteal phase, influenced by hormones like estrogen and progesterone.

Area of Science:

  • Reproductive Endocrinology
  • Hemostasis and Thrombosis

Background:

  • Steroid hormones significantly impact hemostasis.
  • Hormonal influences are noted in hormone replacement therapy, pregnancy, and the ovarian cycle.

Purpose of the Study:

  • To investigate primary hemostasis parameters during the follicular and luteal phases of the natural ovarian cycle.
  • To assess the impact of hormonal fluctuations on platelet function and coagulation factors.

Main Methods:

  • Utilized a platelet function analyzer (PFA-100) to measure closure time (CT).
  • Analyzed 18 healthy women without oral contraceptives across follicular and luteal phases.
  • Measured von Willebrand factor, fibrinogen, fibrinogen degradation products, and other coagulation markers.

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Main Results:

  • Closure time (CT) in collagen/epinephrine cartridges significantly decreased in the luteal phase (P = 0.0095).
  • Negative correlations observed between CT and von Willebrand factor in both cycle phases (r = -0.53 to -0.54).
  • Fibrinogen and fibrinogen degradation products were significantly elevated in the luteal phase (P = 0.02).

Conclusions:

  • Platelet function is periodically altered during the ovarian cycle.
  • Estrogen and progesterone influence von Willebrand factor concentrations, affecting platelet function.
  • The ovarian cycle represents a physiological state with distinct hemostatic profiles.