Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Technology evaluation: EPI-2010, EpiGenesis.

¹EPIX Medical Inc, Cambridge, MA 02142-1118, USA. zzhang@epixmed.com

Current Opinion in Molecular Therapeutics

|July 26, 2002

Summary

EpiGenesis is developing EPI-2010, an antisense oligonucleotide, to potentially treat asthma by blocking the adenosine A1 receptor. This novel approach targets a key pathway involved in respiratory inflammation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fully Automated Radiosynthesis of [<sup>18</sup>F]mG4P027 for mGluR4 Imaging.

iRadiology·2023

Same author

Detailed radiosynthesis of [<sup>18</sup> F]mG4P027 as a positron emission tomography radiotracer for mGluR4.

Journal of labelled compounds & radiopharmaceuticals·2023

Same author

Organomediated cleavage of benzoyl group enables an efficient synthesis of 1-(6-nitropyridin-2-yl)thiourea and its application for developing <sup>18</sup>F-labeled PET tracers.

Bioorganic chemistry·2022

Same author

Synthesis and Characterization of [<sup>18</sup>F]JNJ-46356479 as the First <sup>18</sup>F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2.

Molecular imaging and biology·2021

Same author

Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2.

Journal of medicinal chemistry·2020

Same author

Current Progress and Perspective: Clinical Imaging of Islet Transplantation.

Life (Basel, Switzerland)·2020

Area of Science:

Pharmacology
Respiratory Medicine
Oligonucleotide Therapeutics

Background:

Asthma is a chronic respiratory disease characterized by airway inflammation.
The adenosine A1 receptor plays a role in modulating airway function and inflammation.
Current asthma treatments aim to manage symptoms and inflammation but may have limitations.

Purpose of the Study:

To investigate the potential of EPI-2010, a novel antisense oligonucleotide, as a treatment for asthma.
To evaluate the mechanism of action of EPI-2010 in blocking adenosine A1 receptor synthesis.

Main Methods:

Development of EPI-2010, a 21-mer phosphorothioate respirable antisense oligonucleotide (RASON).
Targeting the synthesis of the adenosine A1 receptor.

Main Results:

EPI-2010 is designed to inhibit the production of the adenosine A1 receptor.
This inhibition is hypothesized to reduce airway inflammation and improve asthma control.

Conclusions:

EPI-2010 represents a potential new therapeutic strategy for asthma.
Further research and clinical trials are necessary to confirm the efficacy and safety of EPI-2010 for asthma treatment.

Related Experiment Videos