Fully Automated Radiosynthesis of [¹⁸F]mG4P027 for mGluR4 Imaging.

Area of Science:

• Radiochemistry
• Neuroscience
• Medical Imaging

Background:

• Metabotropic glutamate receptor 4 (mGluR4) is a key target for neurological disorders.
• [18F]mG4P027 is a potent positron emission tomography (PET) radiotracer for mGluR4.
• Previous studies showed [18F]mG4P027's promise for translational research.

Purpose of the Study:

• To automate the radiosynthesis of the [18F]mG4P027 tracer.
• To address challenges in the manual radiosynthesis process for automation.
• To ensure a reliable and high-yield production of [18F]mG4P027 for human studies.

Main Methods:

• Modifications to the manual radiosynthesis process were implemented.
• Root causes of automation challenges were identified and resolved.
• Automated radiosynthesis was performed using the TRACERlab FX2N module.

Main Results:

• High-purity radiolabeled [18F]mG4P027 was obtained.
• The automated process yielded the tracer in high yield.
• The produced tracer meets requirements for human studies.

Conclusions:

• Successful automation of [18F]mG4P027 radiosynthesis was achieved.
• The automated method provides a reliable source of high-quality tracer.
• This facilitates future clinical applications and human studies targeting mGluR4.