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Updated: Jul 12, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
Diversity Oriented Clicking for Modular Synthesis
Zifei Wang1, Joshua A Homer1, Elias K Zegeye2
1Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Abstract:
Diversity Oriented Clicking (DOC) fuses the reliability of classical click reactions with the versatility of Fluoride Exchange (FEx) chemistry, in which fluorine atoms bound to sulfur or phosphorus serve as highly selective reaction handles. This integrated platform forms covalent bonds rapidly and under mild, biocompatible conditions, broadening the synthetic toolkit for building molecular complexity. By employing DOC workflows, researchers can create structurally diverse compound libraries and explore previously inaccessible regions of chemical space. DOC holds particular promise in drug discovery where it accelerates the profiling of protein function in disease contexts and streamlines the design, synthesis, and high-throughput screening of novel therapeutic candidates.
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