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[Cut-off point for a positive bronchodilation test].

C Pardos Martínez1, J Fuertes Fernández-Espinar, I Nerín De La Puerta

  • 1Centro de Salud Perpetuo Socorro, Huesca. cpardosm@able.es

Anales Espanoles De Pediatria
|July 26, 2002
PubMed
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A positive bronchodilation test in healthy children (7-14 years) is defined by an increase greater than 9% in forced expiratory volume in one second (FEV1). This finding helps establish a standard for pediatric respiratory assessments.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology
  • Clinical Diagnostics

Background:

  • Establishing normative values for bronchodilation is crucial for accurate diagnosis in pediatric respiratory conditions.
  • Previous studies have not definitively established a threshold for a positive bronchodilation test in healthy children.
  • Understanding bronchodilation responses in healthy children provides a baseline for identifying airway hyperresponsiveness.

Purpose of the Study:

  • To determine the bronchodilation response in healthy children aged 7-14 years.
  • To establish a reliable threshold value for defining a positive bronchodilation test in this pediatric population.
  • To contribute to standardized diagnostic criteria for pediatric asthma and other obstructive lung diseases.

Main Methods:

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  • A cross-sectional study was conducted on 145 healthy, nonsmoking schoolchildren aged 7-14 years.
  • Spirometry was performed before and after administration of salbutamol (0.2 mg) to measure forced vital capacity (FVC) and forced expiratory volume in one second (FEV1).
  • Statistical analyses, including the Kolmogorov-Smirnov test and Student's t-test, were used to analyze the data and determine significance.

    • Main Results:

    • The mean percentage increase in FEV1 compared to the theoretical value was 3.97% (SD 2.65).
    • The 97.5th percentile for FEV1 increase from the theoretical value was 10.25%.
    • The mean percentage increase in FEV1 compared to the previous value was 3.99% (SD 2.63), with the 97.5th percentile at 10.14%.

    Conclusions:

    • An increase of greater than 9% in FEV1, relative to either the theoretical or previous value, defines a positive bronchodilation test in children aged 7-14 years.
    • This threshold provides a standardized criterion for diagnosing reversible airway obstruction in pediatric patients.
    • The findings support the use of a 9% FEV1 increase as a clinically relevant indicator of bronchodilation in healthy children.