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[INFECTIONS IN CIRRHOTIC PATIENTS AT HOSPITAL NACIONAL ARZOBISPO LOAYZA IN LIMA,PERU]
Abstract:
Bacterial infections are frecuent in cirrhotic patients, they are present in 30% - 50% of hospitalized cirrhotic and in 10% of general population; compromise 4.5 % of cirrhotic for year.The purpose of this study was to distinguish the prognostic factors of survival and its influence on the evolution of the disease in cirrhotic patients, we have analized 100 patientes with cirrhosis.Alcoholism is the firsth cause of cirrhosis (39%), the second is viral hepatitis (7%), and no defined in 51%.At least 86% of cirrhotic patients had one episode of infection that produced hospitalization The most common infection was: urinary tract (68.6%), spontaneous bacterial peritonitis (11.5%), pneumnonia (11.5%), tuberculosis (3.5%), cellulitis (3.9%) and others (1.8%).Three of each four hospitalizations were caused for intercurrent infection.Child-Poug C and B patients had infections more times that Child-Poug A patients.Global mortality was 59%. Suvival was 83.7% at 2 years and 32.5% at 5 years.
Insights
Bacterial infections significantly impact survival in cirrhotic patients, with high hospitalization rates and mortality. Early identification of prognostic factors is crucial for improving outcomes in liver disease management.
Area of Science:
- Hepatology and Infectious Diseases
- Clinical Medicine
- Gastroenterology
Background:
- Bacterial infections are common in cirrhotic patients, affecting 30%-50% of hospitalizations compared to 10% in the general population.
- These infections represent a significant burden, accounting for 4.5% of cirrhotic cases annually and frequently leading to hospitalizations.
Purpose of the Study:
- To identify prognostic factors influencing survival in cirrhotic patients.
- To analyze the impact of these factors on disease progression and outcomes.
Main Methods:
- Retrospective analysis of 100 cirrhotic patients.
- Evaluation of infection prevalence, types, and correlation with disease severity (Child-Pugh score).
Main Results:
- Alcoholism (39%) and viral hepatitis (7%) are primary causes of cirrhosis.
- 86% of patients experienced at least one infection-related hospitalization; urinary tract infections were most common (68.6%).
- Higher infection rates were observed in Child-Pugh C and B patients compared to A; overall mortality was 59%.
Conclusions:
- Infections are a major complication in cirrhosis, significantly increasing hospitalizations and mortality.
- Disease severity, indicated by Child-Pugh class, correlates with infection frequency.
- Survival rates at 2 and 5 years were 83.7% and 32.5%, respectively, highlighting the critical impact of infections on long-term prognosis.