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Cystic fibrosis in rhinologic practice
Antoni Krzeski1, Dorota Kapiszewska-Dzedzej, Norbert P Górski
1Department of Otorhinolaryngology, Medical University of Warsaw, Poland.
American Journal of Rhinology
|July 27, 2002
Summary
Cystic fibrosis (CF) patients universally exhibit chronic rhinosinusitis (CRS) signs, often more severe than in controls. This study details characteristic CRS manifestations in CF, including nasal polyposis and sinus changes.
Area of Science:
- Otorhinolaryngology
- Genetics
- Pulmonology
Background:
- Cystic fibrosis (CF) is a prevalent, lethal genetic disorder in Caucasian populations.
- Chronic rhinosinusitis (CRS) with extensive nasal polyposis is a recognized manifestation of CF.
Purpose of the Study:
- To ascertain the prevalence and severity of CRS in individuals with CF.
- To identify characteristic clinical and radiological signs of CRS in CF patients.
Main Methods:
- A study was conducted to evaluate CRS in CF patients.
- Comparison with a control group was performed to assess disease severity.
Main Results:
- All CF patients presented with signs and symptoms of CRS.
- CRS in CF patients was more advanced compared to the control group.
- The dF508 gene mutation and CRS duration exceeding 3 years correlated with the most severe paranasal sinus inflammatory changes.
Conclusions:
- Characteristic signs of CRS in CF patients include massive nasal polyposis, a dilated nasal base, and impaired mucociliary clearance.
- Significant radiological findings such as frontal and maxillary sinus hypoplasia, bony destruction, and medial bulging of the lateral nasal wall are indicative of CRS in CF.