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Study on interaction between duodenase protease with dual specificity and inhibitors of bowman-birk family
Inna P Gladysheva Gladysheva1, Natalia A Popykina, Tatyana S Zamolodchikova
1Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, 119899 Russia.
Protein and Peptide Letters
|July 27, 2002
Abstract:
The interaction between duodenase and inhibitors of Bowman-Birk type from soybeans (BBI) and lima beans (LBI) was investigated. Duodenase was shown to interact only with antichymotrypsin site of these inhibitors. The inhibition constants of duodenase by BBI, LBI, BBI-trypsin and LBI trypsin complexes were 4, 23, 400, 600 (n)M respectively.
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