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Updated: Jul 29, 2026

Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
From gavage to oral feedings: just a matter of time
1Department of Developmental Pediatrics, Riley Hospital for Children, Indianapolis, Indiana 46202-5200, USA. pklemons@iupui.edu
Insights
Infants, especially premature ones, achieve oral feeding skills through maturation. Focusing on nutritional support and minimizing stress is more effective than accelerating the feeding process.
Area of Science:
- Neonatology
- Pediatric Gastroenterology
- Developmental Pediatrics
Background:
- Safe and efficient oral feeding relies on oral-motor skills, neurobehavioral organization, and gastrointestinal maturity.
- Premature infants and those with postnatal complications often experience delays in achieving oral feeding milestones.
- Transitioning to oral feeding is a gradual process that may require supplemental gavage or bottle feeding.
Purpose of the Study:
- To explore the factors influencing the transition to oral feeding in infants.
- To understand the challenges faced by premature infants in achieving oral feeding competence.
- To evaluate strategies for facilitating oral intake and identify optimal approaches for supporting infant feeding development.
Main Methods:
- The study reviews existing literature and clinical observations regarding infant oral feeding development.
- It analyzes the impact of prematurity and postnatal complications on feeding milestones.
- It discusses various supportive measures and their effectiveness in facilitating oral intake.
Main Results:
- Infant oral feeding ability is primarily dependent on inherent maturational processes.
- Postnatal complications significantly correlate with delayed onset and achievement of full enteral intake.
- Older infant age at first feeding often correlates with a shorter transition time to full oral feeding.
Conclusions:
- Infant feeding maturation is a time-dependent process that cannot be significantly accelerated.
- Supportive measures can aid oral intake but passage of time is most beneficial.
- Prioritizing adequate nutrition while minimizing infant stress and fatigue is the most effective strategy.
Abstract:
The ability to safely and efficiently feed by mouth is based on oral-motor competence, neurobehavioral organization, and gastrointestinal maturity. Although most infants successfully make the transition to oral feedings as they approach term gestation, infants who were very immature at birth have historically had the most difficulty achieving this milestone. Postnatal complications (chronic lung disease, intraventricular hemorrhage, seizures, and so on) are also associated with delays in the onset of the first feeding, as well as with delays in achieving full enteral intake. Weaning the infant to breast is a slow and gradual process that may necessitate supplemental gavage or bottle feedings. A variety of measures--such as positioning, containment, reduced milk flow, and imposed rest breaks--may help to facilitate better oral intake, but infants probably benefit most from the passage of time. Frequently, the older the infant is at first feeding, the shorter the time required to make the transition to full oral feedings. Rather than attempting to accelerate the inherent maturational processes that form the basis for oral feeding, efforts might better be spent in providing adequate nutritional support while avoiding unnecessary stress and fatigue.
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