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Nerve growth factor and asthma.

S Bonini1, A Lambiase, G Lapucci

  • 1Allergology and Clinical Immunology, Department of Internal Medicine, Second University of Naples, Naples, Italy.

Allergy
|July 30, 2002
PubMed
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Nerve growth factor (NGF) plays a key role in allergic diseases like asthma. Elevated NGF levels correlate with disease severity and inflammation, suggesting it as a therapeutic target.

Area of Science:

  • Immunology
  • Neuroscience
  • Ophthalmology

Background:

  • Nerve growth factor (NGF) influences the nervous and immune systems, impacting allergic conditions.
  • Elevated NGF levels are observed in patients with allergic diseases and asthma, correlating with disease severity.

Purpose of the Study:

  • To investigate the role of NGF in allergic inflammation and asthma.
  • To explore NGF's involvement in tissue remodeling and airway hyperreactivity.

Main Methods:

  • Measured NGF levels in patients with allergic diseases (vernal keratoconjunctivitis, allergic rhinitis, asthma).
  • Assessed NGF production by immune cells (T-helper 2 lymphocytes, mast cells, eosinophils).
  • Evaluated NGF receptor expression and the effect of NGF/anti-NGF treatment in asthma models.

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Main Results:

  • Increased NGF levels and mRNA were found in allergic patients, correlating with inflammation and mast cell infiltration.
  • NGF is produced by key inflammatory cells in allergic responses.
  • NGF administration induced fibroblast activation, while anti-NGF treatment reduced airway hyperreactivity in mice.

Conclusions:

  • NGF is implicated in the pathogenesis of allergic diseases and asthma.
  • NGF may contribute to tissue remodeling and airway hyperresponsiveness.
  • Targeting NGF presents a potential therapeutic strategy for allergic diseases and asthma.