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[Effect of complex therapy including ATP-long on left ventricular diastolic function in patients with ischemic heart
Insights
This study shows ATP-Long improves diastolic function in ischemic heart disease patients. The new metabolic drug enhanced left ventricular diastolic patterns in patients with exertional angina.
Area of Science:
- Cardiology
- Pharmacology
- Biochemistry
Background:
- Ischemic heart disease (IHD) often involves diastolic dysfunction, impacting left ventricular function.
- Impaired relaxation type diastolic dysfunction is a specific concern in stable exertional angina.
- Current treatments aim to improve cardiac function and patient outcomes.
Purpose of the Study:
- To evaluate the efficacy of ATP-Long, a novel metabolic drug, in improving diastolic function in IHD patients.
- To compare the effects of ATP-Long with injectable ATP solution in combined therapy.
- To assess changes in left ventricular diastolic patterns before and after treatment.
Main Methods:
- Doppler echocardiography was used to assess diastolic function at rest and during isometric load.
- 34 patients with stable IHD, functional class I-II exertional angina, and diastolic dysfunction were included.
- Patients received a ten-day course of combined treatment with either ATP-Long or injectable ATP.
Main Results:
- ATP-Long demonstrated an improvement in the temporal patterns of left ventricular diastole.
- Combined treatment with ATP-Long led to enhanced diastolic parameters in IHD patients.
- The study provides evidence for the beneficial effects of this metabolic drug on cardiac diastolic function.
Conclusions:
- ATP-Long, a metabolic drug from Ukraine, is effective in improving diastolic function in IHD patients.
- The drug shows promise as an adjunct therapy for patients with exertional angina and diastolic dysfunction.
- Further research may explore long-term effects and broader applications of ATP-Long in cardiovascular medicine.
Abstract:
The study comprised 34 patients with ischemic heart disease (IHD) stable functional class I-II extertional angina with impaired relaxation type diastolic dysfunction of the left ventricle. Instituted in all patients before and after the combined treatment involving the use of ATP-Long (group I) or ATP solution injectable i.m. (group II) was dopplercardiometry in rest and at the peak of isometric load. The course of ATP treatments administration was ten days in duration. The use in a combined treatment IHD patients of ATP-Long, a new metabolic-action type drug preparation of Ukraine, permits improving parameters of the diastole temporal patterns, as evidenced by results of the studies made.