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Updated: Sep 30, 2026

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
Published on: December 24, 2016
Dendritic cells, antigen distribution and the initiation of primary immune responses to self and non-self antigens
Stella C Knight1, Fiona Burke, Penelope A Bedford
1Antigen Presentation Research Group, Northwick Park Institute for Medical Research, Imperial College Faculty of Medicine, Watford Rd., Harrow HA1 3UJ, UK. s.knight@ic.ac.uk
Abstract:
Immunity or tolerance are determined through the bone marrow-derived, antigen-presenting cells, dendritic cells (DC). Stimulation of lymphocytes by different types of DC, DC at different stages of maturity and DC producing and responding to different growth factors modulate immune responses. Innate receptors for foreign or self antigens provide scope in DC for discrimination between different antigenic stimuli. DC also transfer processed antigens to other DC. We propose that DC do not stimulate responses to antigens in their own environment but only to antigens acquired from other DC, providing a mechanism for discriminating between environmental and non-environmental antigens.
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