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Updated: Sep 30, 2026

Simple Continuous Glucose Monitoring in Freely Moving Mice
Published on: February 24, 2023
[Subcutaneously implantable glucose sensors in patients with diabetes mellitus; still many problems]
M Gerritsen1, J A Jansen, J A Lutterman
1Tweesteden Ziekenhuis, afd. Interne Geneeskunde, Postbus 90.107, 5000 LA Tilburg.
Abstract:
Despite considerable scientific efforts, no clinical method is currently available for the continuous monitoring of glucose in subcutaneous tissue fluid. In general, good results were obtained during in-vitro experiments with various implantable glucose sensors. However, after implantation these devices exhibited a progressive loss of sensor function. It is evident that the tissue reaction to the implanted sensor, especially the interactions at the sensor-tissue interface, plays an important role in this loss of function. Adequate strategies to improve in-vivo sensor performance can only be developed if there is a better understanding of the processes involved in sensor inactivation.
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