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Anti-leukemia effect of resveratrol
Min-Fu Tsan1, Julie E White, Jewraj G Maheshwari
1Office of Research Compliance and Assurance, Department of Veterans Affairs, Washington, DC 20422, USA. min-fu.tsan2@med.va.gov
Leukemia & Lymphoma
|August 1, 2002
Summary
Resveratrol shows potential as an anti-leukemia agent by inhibiting leukemia cell growth and viability. Further research is warranted due to its low toxicity.
Area of Science:
- Phytochemistry
- Molecular Biology
- Oncology
Background:
- Resveratrol is a natural phytoalexin found in fruits, plants, and wine.
- It exhibits various biological activities, with potential cardiovascular and anti-cancer effects.
- Its specific role in coronary heart disease (CHD) remains uncertain.
Purpose of the Study:
- To investigate the anti-leukemia effects of resveratrol.
- To explore the potential mechanisms underlying resveratrol's impact on leukemia cells.
Main Methods:
- In vitro studies on leukemia cell cultures.
- Assessment of cell differentiation, apoptosis, and cell cycle arrest.
- Evaluation of DNA synthesis inhibition.
- Testing on freshly isolated leukemia cells, including promyelocytic leukemia cells.
Main Results:
- Resveratrol preferentially inhibits the growth of leukemia cells in culture.
- Potential mechanisms include inducing differentiation, apoptosis, and cell cycle arrest.
- Resveratrol inhibits DNA synthesis by targeting ribonucleotide reductase or DNA polymerase.
- Preliminary data indicate inhibition of viability in freshly isolated leukemia cells, particularly promyelocytic leukemia cells.
Conclusions:
- Resveratrol demonstrates significant anti-leukemia activity in vitro.
- Its low in vivo toxicity suggests promise as a potential anti-leukemia therapeutic agent.
- Further investigation into resveratrol's anti-leukemia properties is justified.