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Modulation by substrates of the protective effect of cyclosporin A on mitochondrial damage
Edmundo Chávez1, Cecilia Zazueta, Francisco Correa
1Departamento de Bioquímica, Instituto Nacional de Cardiologia, Ignacio Chávez, México, DF, Mexico. echavez@mail.ssa.gob.mx
Life Sciences
|August 2, 2002
Abstract:
The influence of substrates on the role of cyclosporin A, to promote the closure of the permeability transition pore, was studied. It was found that in succinate-oxidizing mitochondria, cyclosporin inhibited pore opening as induced by carboxyatractyloside. The opposite occurred when mitochondrial respiration was supported by malate-glutamate, i.e., cyclosporin A was unable to block pore opening promoted by carboxyatractyloside. We propose that the failure of cyclosporin A to induce pore closure could be due to a low NADH matrix content.