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Related Experiment Videos

Basic fibroblast growth factor in human saliva decreases with aging.

Anders Westermark1, Ilmari Pyykkö, Mikael Magnusson

  • 1Department of Maxillofacial Surgery, Karolinska Hospital, Stockholm, Sweden. anders.westermark@ks.se

The Laryngoscope
|August 2, 2002
PubMed
Summary

Saliva contains basic fibroblast growth factor (bFGF), crucial for tissue repair. This study found bFGF levels significantly decrease with age, being highest in children and lowest in the elderly.

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Area of Science:

  • Biochemistry
  • Physiology
  • Gastroenterology

Background:

  • Basic fibroblast growth factor (bFGF) plays a vital role in wound healing and tissue repair.
  • bFGF is implicated in maintaining the integrity of the upper digestive tract mucosa.

Purpose of the Study:

  • To investigate age-dependent variations in human saliva basic fibroblast growth factor (bFGF) concentration.

Main Methods:

  • A cross-sectional pilot study involving 182 healthy volunteers aged 4 to 97 years.
  • Saliva samples collected via drooling.
  • Quantification of bFGF concentration using a commercial enzyme-linked immunosorbent assay (ELISA) kit.

Main Results:

  • Mean saliva bFGF concentration was 0.41 pg/mL, with no significant gender differences.

Related Experiment Videos

  • Significantly higher bFGF levels were observed in younger age groups (4-19 years: 0.72 pg/mL) compared to middle-aged (20-65 years: 0.33 pg/mL) and elderly individuals (66-97 years: 0.005 pg/mL).
  • Saliva bFGF concentration exhibited greater variability in the youngest age group.

    • Conclusions:

    • Human saliva bFGF concentration demonstrates significant age-dependent variations.
    • Highest bFGF levels are found in young individuals, decreasing through adulthood and reaching minimal levels in the elderly.
    • These findings suggest a physiological role for bFGF in saliva across the human lifespan.